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  •  Институт физико-органической химии НАН Беларуси

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Azide Phosphoramidite in Direct Synthesis of Azide-Modified Oligonucleotides

Fomich M. A., Kvach M. V., Navakouski M. J., Weise C., Baranovsky A. V., Korshun V. A., Shmanai V. V.

Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at −20 °C. An azide-carrying phosphoramidite was used for direct introduction of multiple azide modifications into synthetic oligonucleotides. A series of azide-containing oligonucleotides were modified further using click reactions with alkynes.

Organic Letters 2014, 16 (17), 4590–4593

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