The air and moisture stable square-planar trans-dichloro palladium (II) complex containing 5-(p-tolyl)isoxazol-3-amine ligand was synthesized and structurally characterized by single crystal X-ray diffraction. The isoxazol-3-amine ligand was prepared from the 5-(p-tolyl)isoxazole-3-carbaldehyde oxime by the series of successive transformations. The new complex is a high-turnover-number catalyst for Suzuki-Miyaura reaction with low Pd loading (0.0001 — 0.1%) in neat water under air atmosphere.
Original Text © Synthesis. 2012. Vol. 44. N 1. P. 151-157.