Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at −20 °C. An azide-carrying phosphoramidite was used for direct introduction of multiple azide modifications into synthetic oligonucleotides. A series of azide-containing oligonucleotides were modified further using click reactions with alkynes.
Organic Letters 2014, 16 (17), 4590–4593